Charles Pierce may refer to:Charles Wilson Pierce (1823–1907), U.S. Representative from Alabama
Charlie W. Pierce (1864–1939), Florida pioneer and author
Charles H. Pierce (1875–1944), Philippine–American War Medal of Honor recipient
Charlie Pierce (footballer) (1917–2007), Australian rules footballer
Charles Pierce (1926–1999), American female impersonator
Charles B. Pierce (1938–2010), American film director
Charlie Pierce, American sportswriter, political blogger, and author